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Public studies on ingredients:
Animal Study, Bacterial, Human In Vitro, Human Study, In Vitro Study.

Research & Studies:

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PUMKIN - Cucurbita maxima

There are 167 good studies at Pumpkin. Here's a selection:
Abstracts with Pumpkin Research:

Pumpkin seed oil and saw palmetto oil may be effective as complementary and alternative medicine treatments for benign prostatic hyperplasia.
Abstract Title:
Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia.
Abstract Source:
Nutr Res Pract. 2009 ;3(4):323-7. Epub 2009 Dec 31. PMID: 20098586
Abstract Author(s):
Heeok Hong, Chun-Soo Kim, Sungho Maeng
Article Affiliation:
Heeok Hong
This study was to investigate the role of complementary and alternative medicine in the prevention and treatment of benign prostatic hyperplasia. For this purpose, a randomized, double-blind, placebo-controlled trial was performed over 12 months on 47 benign prostatic hyperplasia patients with average age of 53.3 years and international prostate symptom score over 8. Subjects received either sweet potato starch (group A, placebo, 320 mg/day), pumpkin seed oil (group B, 320 mg/day), saw palmetto oil (group C, 320 mg/day) or pumpkin seed oil plus saw palmetto oil (group D, each 320 mg/day). International prostate symptom score, quality of life, serum prostate specific antigen, prostate volume and maximal urinary flow rate were measured. In groups B, C and D, the international prostate symptom score were reduced by 3 months. Quality of life score was improved after 6 months in group D, while those of groups B and C were improved after 3 months, compared to the baseline value. Serum prostate specific antigen was reduced only in group D after 3 months, but no difference was observed in prostate volume in all treatment groups. Maximal urinary flow rate were gradually improved in groups B and C, with statistical significance after 6 months in group B and after 12 months in group C. None of the parameters were significantly improved by combined treatment with pumpkin seed oil and saw palmetto oil. From these results, it is suggested that administrations of pumpkin seed oil and saw palmetto oil are clinically safe and may be effective as complementary and alternative medicine treatments for benign prostatic hyperplasia.
Article Published Date : Dec 31, 2008
Study Type : Human Study
Additional Links
Substances : Pumpkin : CK(147) : AC(34), Saw Palmetto : CK(152) : AC(23)
Diseases : Prostatic Hyperplasia: Benign : CK(256) : AC(59)

You will find much more in the following links on the Pumpkin:

A flax and pumpkin seed mixture has anti-atherogenic and hepatoprotective effects.
Abstract Title:
Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in omega-3 and omega-6 fatty acids in hypercholesterolemic rats.
Abstract Source:
Food Chem Toxicol. 2008 Dec;46(12):3714-20. Epub 2008 Oct 1. PMID: 18938206
Abstract Author(s):
M Makni, H Fetoui, N K Gargouri, El M Garoui, H Jaber, J Makni, T Boudawara, N Zeghal
Article Affiliation:
Animal Physiology Laboratory, Sciences Faculty, UR 08-73, BP 1171, Tunisia.
Flax and pumpkin seeds are a rich source of unsaturated fatty acids, antioxidants and fibers, known to have anti-atherogenic and hepatoprotective activities. These effects were evaluated in Wistar rats fed with 1% cholesterol diet. The study was performed on 30 male rats divided into three groups: a control group (CD), CD-chol group fed diet with 1% cholesterol and MS-chol group fed diet enriched with flax and pumpkin seed mixture. In CD-chol group, total cholesterol TC, triacylglycerol TG in plasma and liver, plasma LDL-C, atherogenic index AI and LDL/HDL ratio significantly increased. In MS-chol group lipid parameters decreased significantly, plasma and liver fatty acid composition showed an increase of PUFAs (ALA and LA), and MUFAs (oleic and eicosaenoic acid) and a decrease of SFA (palmitic and stearic acid). In plasma and liver of MS-chol group, malondialdehyde levels decreased and the efficiency of antioxidant defense system was improved compared to CD-chol group. Liver histological sections showed lipid storage in hepatocytes of CD-chol group and an improvement was noted in MS-chol group. Our results suggested that flax and pumpkin seed mixture had anti-atherogenic and hepatoprotective effects which were probably mediated by unsaturated fatty acids present in seed mixture.
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Flaxseed : CK(499) : AC(97), Omega-3 Fatty Acids : CK(3849) : AC(463), Pumpkin Seed Oil/Meal : CK(98) : AC(21)
Diseases : Arteriosclerosis : CK(452) : AC(126), High Cholesterol : CK(1774) : AC(271)
Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective

Nectary Proteome A total of 339 proteins were detected in the nectaries of male and female C. maxima flowers using iTRAQ
PUMPKIN - Cucurbita maxima
PUMPKIN - Cucurbita maxima

22 Pharmacological Actions Researched for Pumpkin - Cucurbita maxima :
Anti-Inflammatory Agents313
Antihypertensive Agents212
Anticholesteremic Agents110
Hypoglycemic Agents110
Malondialdehyde Down-regulation36
Bcl-2 protein down-regulation15
Antiparasitic Agents12
Catalase Up-Regulation12
Neuroprotective Agents12
Superoxide Dismutase Up-regulation12


Evaluation the Effects of Some Relevant Parameters on Elastic Modulus of Pumpkin Seed and Its Kernel. Effect of size on elastic modulus of pumpkin seed and its kernel. Mohammad Hossein Abbaspour-Fard, et al. Int J Biomater. 2012;2012:271650
Virgin pumpkin seed oil reduces circulating markers of inflammation in cholesterol-fed ApoE*3Leiden mice.. From: Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil. Mice were fed a Western type control diet (CON) or CON diet containing 9% refined pumpkin seed oil (REF) or 9% virgin pumpkin seed oil (VIR) for 20 weeks. A: Plasma SAA levels were reduced by VIR. Liver damage marker B: ASAT and C: ALAT were reduced by VIR but not by REF. D: Plasma sVCAM-1 levels in VIR animals were lower throughout the duration of the study. Data are mean±SEM. * p≤0.05, ** p≤0.01 compared with CON. # p≤0.05 for VIR compared with REF. Martine C. Morrison, et al. PLoS One. 2015;10(9):e0139196
Penetration of nanoparticles into individual cells of the parenchyma. A) Phase contrast image showing the relative position of the cells carrying nanoparticles (squared) respect to the location of nanoparticle deposits in the pith cavity (arrows). B) TEM image of a region equivalent to the one squared in (A). Nanoparticles are electron dense, and appear surrounded by organelles. C) High magnification of the region squared in (B). Nanoparticles are aggregated. The cellular structures close to them show bright white inclusions. Bar in A = 20 μm; B and C = 2 μm.

PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books. 
In PubMed
There are  6642 on Pumpkin.

44 Diseases Researched for Pumpkin - Cucurbita maxima :
Prostatic Hyperplasia: Benign524
Anemia: Iron Deficiency110
Anti-Social Behavior110
Anxiety Disorders110
Bladder Stones110
C-Reactive Protein110
Diabetes Mellitus: Type 2110
HDL: Low110
Hot Flash110
Kidney Failure: Acute110
Lung Cancer: Prevention110
Overactive Bladder110
Phobia: Social110
Postmenopausal Disorders110
Triglycerides: Elevated110
Liver Cancer27
Parasitic Intestinal Diseases24
Prostatic Hyperplasia, Testosterone-Induced24
Oxidative Stress23
Acetaminophen (Tylenol) Toxicity12
Athletic Performance12
Chemically-Induced Liver Damage12
Diabetic Nephropathy12
Drug Toxicity: Methotrexate12
Gastrointestinal Hemorrhage12
High Cholesterol12
Lipid Peroxidation12
Protein Malnourishment12
Tapeworm Infection12
Wound Healing12
Breast Cancer11
Colon Cancer11
Hydrogen Peroxide Induced Toxicity11
Lower Urinary Tract Symptoms11
Prostate Cancer11

Germanium Does Not Substitute for Boron in Cross-Linking of Rhamnogalacturonan II in Pumpkin Cell Walls. Scanning electron micrographs of the broken petiole ends from the second leaf of B-deficient and Ge-treated (28 μm) pumpkin plants. A, Petiole from Ge-treated plant; B, petiole from B-deficient plant. Scale bar = 100 μm. Tadashi Ishii, et al. Plant Physiol. 2002 Dec;130(4):1967-1973
Claims of "substantial equivalence" of GM plants again shown to be false

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