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Research & Studies:

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Nettle/Stinging Nettle

There are 83 good studies at Nettle. Here's a selection:
Abstracts with Nettle Research

Nettle extract might prove to be effective for stress mediated neurological disorders.
Abstract Title:
Urtica dioica leaves modulates hippocampal smoothened-glioma associated oncogene-1 pathway and cognitive dysfunction in chronically stressed mice.
Abstract Source:
Biomed Pharmacother. 2016 Jul 28 ;83:676-686. Epub 2016 Jul 28. PMID: 27470568
Abstract Author(s):
Sita Sharan Patel, Neeraj Mahindroo, Malairaman Udayabanu
Article Affiliation:
Sita Sharan Patel
The present study was aimed to evaluate the effect of Urtica dioica (UD) extract against chronic unpredictable stress (CUS)-induced associative memory dysfunction and attempted to explore the possible mechanism. Male Swiss albino mice (25-30g) were divided into six groups, viz. group-I received 0.3% carboxymethyl cellulose and served as control (CTRL), group II was exposed to CUS (21days) and received vehicle (CUS), group III was subjected to CUS and received Hypericum perforatum extract (350mg/kg, p.o.) (CUS+HYP), group IV received Hypericum perforatum extract (350mg/kg, p.o.) (CTRL+HYP); group V was subjected to CUS and received UD extract (50mg/kg, p.o.) (CUS+UD), group VI received UD extract (50mg/kg, p.o.) (CTRL+UD). CUS significantly induced body weight loss (p<0.05) and associative memory impairment in step down task (p<0.05) as compared to control mice. CUS significantly downregulated Smo (p<0.05), Gli1 (p<0.01), cyclin D1 (p<0.05), BDNF (p<0.01), TrKB (p<0.01) and MAPK1 (p<0.01) mRNA expression in hippocampus as compared to control mice. CUS significantly increased the levels of TBARS (p<0.01) and nitric oxide (p<0.001), and decreased catalase (p<0.001) and total thiol (p<0.01) in plasma resulting in oxidative stress and inflammation. Chronic UD administration significantly reverted CUS mediated body weight loss (p<0.05) and cognitive impairment (p<0.05). UD administration significantly decreased the levels of TBARS (p<0.01) and nitric oxide (p<0.05), and increased the levels of catalase (p<0.01) and total thiol (p<0.05) in plasma. Chronic UD administration significantly upregulated hippocampal Smo (p<0.05), Gli1 (p<0.001), cyclin D1 (p<0.05), BDNF (p<0.05), TrKB (p<0.05) and MAPK1 (p<0.05) in stressed mice. Further, UD extract did not reverse cyclopamine induced downregulation of Gli1 and Ptch1 mRNA in hippocampal slices. UD modulated Smo-Gli1 pathway in the hippocampus as well as exerted anti-inflammatory and antioxidant effects. UD extract might prove to be effective for stress mediated neurological disorders.
Article Published Date : Jul 27, 2016
Study Type : Animal Study
Additional Links
Substances : Nettle : CK(184) : AC(73)
Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Stress : CK(623) : AC(103)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Catalase Up-Regulation : CK(118) : AC(42), Nitric Oxide Inhibitor : CK(223) : AC(108)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Nettle extract can decrease the growth of breast tumors and induce apoptosis in tumor cells.

Abstract Title:
Urtica dioica Extract Inhibits Proliferation and Induces Apoptosis and Related Gene Expression of Breast Cancer Cells In Vitro and In Vivo.
Abstract Source:
Clin Breast Cancer. 2017 Apr 21. Epub 2017 Apr 21. PMID: 28501502
Abstract Author(s):
Ali Mohammadi, Behzad Mansoori, Pooneh Chokhachi Baradaran, Vahid Khaze, Mahyar Aghapour, Mehrdad Farhadi, Behzad Baradaran
Article Affiliation:
Ali Mohammadi
INTRODUCTION: Currently, because the prevalence of breast cancer and its consequent mortality has increased enormously in the female population, a number of studies have been designed to identify natural products with special antitumor properties. The main purpose of the present study was to determine the effect of Urtica dioica on triggering apoptosis and diminishing growth, size, and weight of the tumor in an allograft model of BALB/c mice.
MATERIALS AND METHODS: In the present study, a BALB/c mouse model of breast cancer (4T1) was used. After emergence of tumor, 2 groups of mice received the extract, 1 group at a dose of 10 mg/kg and 1 group at a dose of 20 mg/kg, by intraperitoneal injection for 28 days. During the test and after removal of the tumor mass, the size and weight of the tumor were measured. To assess the induction of apoptosis in the cancer cells, the TUNEL (terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling) assay was performed. The Ki-67 test was used to evaluate tumor proliferation.
RESULTS: The results showed that the tumor size in the mice treated with the extract decreased significantly. The weight of the tumor mass in the treated mice after resection was less than that in the control group. The TUNEL assay findings revealed that apoptosis occurred in the treated group. The Ki-67 test findings also demonstrated that administration of the extract suppressed the growth of tumor cells.
CONCLUSION: These results suggest that U. dioica extract can decrease the growth of breast tumors and induce apoptosis in tumor cells; thus, it might represent an ideal therapeutic tool for breast cancer.
Article Published Date : Apr 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Nettle : CK(184) : AC(73)
Diseases : Breast Cancer : CK(3592) : AC(1064)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)

The in vivo data from this study suggested that UD and exercise training could cure diabetic rats.

Abstract Title:
In vivo and in vitro evaluation of the effects of Urtica dioica and swimming activity on diabetic factors and pancreatic beta cells.
Abstract Source:
BMC Complement Altern Med. 2016 ;16(1):101. Epub 2016 Mar 15. PMID: 26980377
Abstract Author(s):
Abbas Ranjbari, Mohammad Ali Azarbayjani, Ashril Yusof, Abdul Halim Mokhtar, Samad Akbarzadeh, Mohamed Yousif Ibrahim, Bahman Tarverdizadeh, Parviz Farzadinia, Reza Hajiaghaee, Firouzeh Dehghan
Article Affiliation:
Abbas Ranjbari
BACKGROUND: Urtica dioica (UD) has been identified as a traditional herbal medicine. This study aimed to investigate the effect of UD extract and swimming activity on diabetic parameters through in vivo and in vitro experiments.
METHODS: Adult WKY male rats were randomly distributed in nine groups: intact control, diabetic control, diabetic + 625 mg/kg, 1.25 g/kg UD, diabetic + 100 mg/kg Metformin, diabetic + swimming, diabetic + swimming 625 mg/kg, 1.25 g/kg UD, and diabetic +100 mg/kg Metformin + swimming. The hearts of the animals were punctured, and blood samples were collected for biochemical analysis. The entire pancreas was exposed for histologic examination. The effect of UD on insulin secretion by RIN-5F cells in 6.25 or 12.5 mM glucose dose was examined. Glucose uptake by cultured L6 myotubes was determined.
RESULTS: The serum glucose concentration decreased, the insulin resistance and insulin sensitivity significantly increased in treated groups. These changes were more pronounced in the group that received UD extract and swimming training. Regeneration and less beta cell damage of Langerhans islets were observed in the treated groups. UD treatment increased insulin secretion in the RIN-5F cells and glucose uptake in the L6 myotubes cells.
CONCLUSIONS: Swimming exercises accompanied by consuming UD aqueous extracts effectively improved diabetic parameters, repaired pancreatic tissues in streptozotocin-induced diabetics in vivo, and increased glucose uptake or insulin in UD-treated cells in vitro.
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Nettle : CK(184) : AC(73)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Diabetes Mellitus: Type 2: Prevention : CK(651) : AC(86), Insulin Resistance : CK(1683) : AC(346)
Therapeutic Actions : Exercise: Swimming : CK(8) : AC(4)
Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342), Insulin Sensitizers : CK(350) : AC(70), Regenerative : CK(52) : AC(28)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)


Natural herbs are safe, effective and better options as anti-inflammatory agents than synthetic ones.

Abstract Title:
Anti-Inflammatory Drugs and Herbs with Special Emphasis on Herbal Medicines for Countering Inflammatory Diseases and Disorders - A Review.
Abstract Source:
Recent Pat Inflamm Allergy Drug Discov. 2018 Jan 15. Epub 2018 Jan 15. PMID: 29336271
Abstract Author(s):
Mohd Iqbal Yatoo, Arumugam Gopalakrishnan, Archana Saxena, Oveas Rafiq Parray, Noore Alam Tufani, Sandip Chakraborty, Ruchi Tiwari, Kuldeep Dhama, Hafiz M N Iqbal
Article Affiliation:
Mohd Iqbal Yatoo
BACKGROUND: Diseases with inflammatory etiopathology have increased in incidence in recent times. Drugs used for therapeutic management of such inflammatory diseases are relieving the ailment but at the same time also countering serious life-threatening consequences. Moreover, they are costly and rarely available at all places. In this context, research and development on medicinal herbs have opened a new era in the prophylactic and therapeutic management of inflammatory diseases.
OBJECTIVE: To highlight the importance of anti-inflammatory medicine-synthetic drugs and natural herbs, their constituents, mechanism of action, benefits, side effects and future prospects. The overall aim is to provide better health services to patiens regardless of their background on equality basis.
RESULTS: Anti-inflammatory herbs have proven beneficial by combating inflammatory responses that lead to severe abnormality in body systems. Inflammation though a protective response to infection or injury and may result in pathological outcome when aggravated or of severe degree thus needs an early intervention for proper resolution. Medicinal plants or their constituents are considered beneficial due to the properties i.e., satisfactory potency, ease of availability, cheapness, less or no side effects, safer and efficient as compared to the synthetic counterparts. These medicinal herbs contain phytoconstituents that can prevent undesirable inflammatory processes and also posses anti-inflammatory activity. Steroids, glycosides, phenolics, flavonoids, alkaloids, polysaccharides, terpenoids, cannabinoids, fatty acids are common phytoconstituents present in these plants. Different mechanisms have been explored for the anti-inflammatory action of these active ingredients. They may synergize the anti-inflammatory pathway enzymes, factors, proteins or interfere with these in the inflammatory pathway like lipooxygenases, cyclooxygenases, tumor necrosis factors, interleukins, prostaglandin, nitric oxide, mitogen-activated protein, nuclear factor, etc. Considering all the above-mentioned factors, further research from molecular to cellular level will enable a better understanding of the mechanisms. Common anti-inflammatory herbal plants are Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis, Urtica dioica, Uncaria tomentosa, Vaccinium myrtillus, Olea europaea and much more. They are believed to be without side effects unlike the chemical counterparts or synthetic anti-inflammatory agents e.g. steroids, nonsteroid anti-inflammatory drugs, and immunosuppressant used for controlling and suppressing inflammatory crisis. A proper phytochemical, pharmacological and physiological evaluation will enable their safe and effective use in inflammatory conditions. Many of these anti-inflammatory drugs and herbal preparations have been patented with some under consideration.
CONCLUSION: Natural herbs are safe, effective and better options as anti-inflammatory agents than synthetic ones. The phytoconstituents are as effective with the comparable mechanism of action as synthetic molecules. Future research should focus on molecular mechanisms of different beneficial applications of these herbal plants in various diseases. Recent patents on anti-inflammatory drugs and herbal plants have been covered which provide insight into the current status and future prospects in this field.
Article Published Date : Jan 14, 2018
Study Type : Review
Additional Links
Substances : Blueberry : CK(334) : AC(112), Cat's Claw : CK(58) : AC(25), Ginger : CK(775) : AC(207), Nettle : CK(184) : AC(73), Olive : CK(562) : AC(178), Turmeric : CK(5583) : AC(2569)
Diseases : Inflammation : CK(3240) : AC(882)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)


You will find much more in the following links on the Nettle:


Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders.
Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders.

Nettle/Stinging Nettle
PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books. 
In PubMed
There are  1040 on Nettle.

65 Diseases Researched for Nettle:

Diabetes Mellitus: Type 21058
Oxidative Stress720
Insulin Resistance416
Prostatic Hyperplasia: Benign314
C-Reactive Protein110
Diabetes: Oxidative Stress110
Prostatitis: Chronic110
Urinary Flow Problems110
Breast Cancer34
Diabetic Complications24
Lipid Peroxidation24
Prostate Cancer33
Wound Healing23
Alzheimer's Disease12
Androgen-Induced Diseases12
Bleeding: Excessive12
Brain Inflammation12
Brain: Oxidative Stress12
Breast Cancer: Triple Negative22
Chemically-Induced Liver Damage12
Chemotherapy-Induced Toxicity: Cisplatin12
Chronic Pain12
Cognitive Decline/Dysfunction12
Depressive Disorder12
Diabetes Mellitus: Type 2: Prevention12
Diabetic Nephropathy12
Diabetic Neuropathy12
Gastric Ulcer12
High Fructose Diet12
Memory Disorders12
Memory Disorders: Drug-Induced12
Memory Loss12
Mercury Poisoning12
Nicotine/Tobacco Toxicity12
Parkinson's Disease12
Pesticide Toxicity12
Severe Acute Respiratory Syndrome12
Surgery: Oral12
Arthritis: Rheumatoid11
Colon Cancer11
Colorectal Cancer11
Gastric Cancer11
HIV Infections11
Inflammatory Bowel Diseases11
Liver Cancer11
Rheumatoid Arthritis11
Rotavirus Infections11
Staphylococcus aureus infection11
Staphylococcus aureus: Methicillin-resistant (MRSA)11

59 Pharmacological Actions Researched for Nettle:

Anti-Inflammatory Agents1431
Hypoglycemic Agents830
Interleukin-6 Downregulation314
Superoxide Dismutase Up-regulation212
Nitric Oxide Enhancer110
Tumor Necrosis Factor (TNF) Alpha Inhibitor35
Neuroprotective Agents24
Antiviral Agents23
Cell cycle arrest33
Cyclooxygenase 2 Inhibitors23
Malondialdehyde Down-regulation23
Nitric Oxide Inhibitor23
Anti-Anxiety Agents12
Anti-Ulcer Agents12
Anticholesteremic Agents12
Antidepressive Agents12
Antihypertensive Agents12
Calcium Channel Blockers12
Catalase Up-Regulation12
Chemoprotective Agents12
Glutathione Upregulation12
Insulin Sensitizers12
Interleukin-1 beta downregulation12
Pancreato Protective Agents12
Vasodilator Agents12
12-lipoxygenase (12-LOX)11
Adenosine deaminase inhibitor11
Alpha-amylase inhibitor11
Alpha-glucosidase inhibitor11
Anti-Bacterial Agents11
Anticarcinogenic Agents11
Antimutagenic Agents11
Bcl-2 protein down-regulation11
Matrix Metalloproteinase-13 (MMP-13) Inhibitor11
Matrix metalloproteinase-1 (MMP-1) inhibitor11
Matrix metalloproteinase-9 (MMP-9) inhibitor11
MicroRNA modulator11

Topical herbal therapies for treating osteoarthritis. Comparison 5 Stinging nettle versus placebo, Outcome 2WOMAC 0–4 (Stiffness) at 4 weeks. Melainie Cameron, et al. Cochrane Database Syst Rev. ;5:CD010538-CD010538.
Antioxidant Activities and Oxidative Stabilities of Some Unconventional Oilseeds. Changes produced in the region between 2,500 and 4,000 cm−1 the FTIR spectrum of stinging nettle oil on different days of the process Sibel Uluata, et al. J Am Oil Chem Soc. 2012 Apr;89(4):551-559

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