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Public studies on ingredients:
Animal Study, Bacterial, Human In Vitro, Human Study, In Vitro Study.

Research & Studies:

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There are 32 good studies at Natto. Here's a selection:
Abstracts with Natto Research

Natto, a rich source of vitamin K2, promotes bone formation in premenopausal women.
Abstract Title:
Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women.
Abstract Source:
J Nutr Sci Vitaminol (Tokyo). 2004 Apr;50(2):114-20. PMID: 15242015
Abstract Author(s):
Hironobu Katsuyama, Seiji Ideguchi, Masao Fukunaga, Tatsushige Fukunaga, Kiyofumi Saijoh, Shigeo Sunami
A therapeutic agent of vitamin K2 is approved for the treatment of osteoporosis in Japan. However, little is known about the efficacy of dietary intake of vitamin K2 for bone health. We compared the effects of various levels of fermented soybeans (Natto) intake, which contains plenty of vitamin K2, on bone stiffness and bone turnover markers in healthy premenopausal women. Seventy-three healthy premenopausal women were randomly divided into four groups matched for age and parity categories. Natto was supplied as follows: Group 1 (no intake), Group 2 (once per month), Group 3 (once per week) and Group 4 (three times per week). Subjects took Natto at a lunch for 1 y, and the stiffness index by quantitative ultrasound and bone turnover markers were assessed at baseline, 6 mo and 1 y. There was no statistical difference in the stiffness index during the 1 y observation. However, bone specific alkaline phosphatase (BAP) in Group 4 was higher than that in Group 3 at 1 y and undercarboxylated osteocalcin (Glu) in Group 4 was significantly lower than those in Groups 1, 2 and 3 at 6 mo. Logistic regression analysis showed that the risk of reduction of bone formation markers declined to 0.07 in Group 4 based on that in Group 1. In premenopausal women who had to keep the stiffness index as high as possible before menopause, Natto intake may have contributed to the promotion of bone formation.
Article Published Date : Apr 01, 2004
Study Type : Human Study
Additional Links
Substances : Natto : CK(141) : AC(24), Vitamin K : CK(722) : AC(100)
Diseases : Osteoporosis : CK(1302) : AC(257)
Nattokinase supplementation is an effective way to manage the progression of atherosclerosis and potentially may be a better alternative to statins.
Abstract Title:
[A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia].
Abstract Source:
Zhonghua Yi Xue Za Zhi. 2017 Jul 11 ;97(26):2038-2042. PMID: 28763875
Abstract Author(s):
N N Ren, H J Chen, Y Li, G W Mcgowan, Y G Lin
Article Affiliation:
N N Ren
Objective: To evaluate the efficacy of oral nattokinase (NK) in the reduction of common carotid artery intimal medial thickness (CCA-IMT) and carotid artery plaque size and in lowering blood lipids, and to explore the underlying mechanism of actions of NK and its potential clinical use. Methods: All enrolled patients were from the Out-Patient Clinic of the Department of TCM at the 3(rd) Affiliated Hospital of Sun Yat-sen University. Using randomised picking method, all patients were randomly assigned to one of two groups, NK and Statin (ST) group. NK Group-patients were given NK at a daily dose of 6 000 FU and ST Group-patients were treated with statin (simvastatin 20 mg) daily. The treatment course was 26 weeks. CCA-IMT, carotid plaque size and blood lipid profile of the patients were measured before and after treatment. Results: A total of 82 patients were enrolled in the study and 76 patients (NK 39, ST 37) completed the study. Following the treatments for 26 weeks, there was a significant reduction in CCA-IMT and carotid plaque size in both groups compared with the baseline before treatment. The carotid plaque size and CCA-IMT reduced from(0.25±0.12)cm(2) to (0.16±0.10)cm(2) and from (1.13±0.12)mm to (1.01±0.11)mm, repectively. The reduction in the NK group was significantly profound (P<0.01, 36.6% reduction in plaque size in NK group versus 11.5% change in ST group). Both treatments reduced total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG). While the reduction in both groups was shown to be statistically significant (P<0.01), the reduction of TC, LDL-C and TG in ST group was significantly greater (P<0.05). In addition, NK significantly increased the level of high-density lipoprotein cholesterol (HDL-C) (P<0.05), in contrast, HDL-C in the ST group did not change. The lipid lowering effect observed in the NK group was not correlated to the reduction of CCA-IMT and carotid artery plaque size (r=0.35, P=0.09). Conclusions: Our findings from this pioneer clinical study suggests that daily NK supplementation is an effective way to manage the progression of atherosclerosis and potentially may be a better alternative to statins which are commonly used to reduce atherosclerosis and further to prevent cardiovascular attack and stroke in patients. The mechanism underlying the reduction of carotid atherosclerosis by NK may be independent from its lipid-lowering effect, which is different from that of statins.
Article Published Date : Jul 10, 2017
Study Type : Human Study
Additional Links
Substances : Nattokinase : CK(81) : AC(14)
Diseases : Atherosclerosis : CK(601) : AC(150), Hyperlipidemia : CK(670) : AC(155)
Pharmacological Actions : Anti-atherogenic : CK(156) : AC(39), Hypolipidemic : CK(1288) : AC(265)

You will find much more in the following links on the Natto:

Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats.



PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books. 
In PubMed
There are  12581 on Natto.
There are 126 on Nattokinase.

20 Diseases Researched for Fucoidan
Deep Vein Thrombosis110
Intima Media Thickening26
Alzheimer's Disease12
Nerve Injuries12
Peripheral Nerve Diseases12
Aging Skin11
Bone Fractures11
Brain Ischemia11
Cardiovascular Diseases

17 Pharmacological Actions Researched Natto:
Anticholesteremic Agents110
Antihypertensive Agents110
Platelet Aggregation Inhibitors110
Fibrinolytic Agents25
Neuroprotective Agents23
Interleukin-6 Downregulation12
Tumor Necrosis Factor (TNF) Alpha Inhibitor12
Malondialdehyde Down-regulation11
Superoxide Dismutase Up-regulation11

The Antithrombotic and Fibrinolytic Effect of Natto in Hypercholesterolemia Rats.

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