ninfo.se   
medforsk laboratories


ninfo.se    Research and development      guarantees/certificates  

Public studies on ingredients:
Animal Study, Bacterial, Human In Vitro, Human Study, In Vitro Study.

Research & Studies:

"Do not tell everything. You can be stopped. Truth is not in everyone's interest."

Dandelion

There are 75 good studies at Dandelion. Here's a selection:
Abstracts with Dandelion Research

2009
Dandelion has a diuretic effect in human subjects.
Abstract Title:
The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day.
Abstract Source:
J Altern Complement Med. 2009 Aug;15(8):929-34. PMID: 19678785
Abstract Author(s):
Bevin A Clare, Richard S Conroy, Kevin Spelman
Abstract:
BACKGROUND: Taraxacum officinale (L.) Weber (Asteraceae) has been extensively employed as a diuretic in traditional folk medicine and in modern phytotherapy in Europe, Asia, and the Americas without prior clinical trial substantiation. OBJECTIVES: In this pilot study, a high-quality fresh leaf hydroethanolic extract of the medicinal plant T. officinale (dandelion) was ingested by volunteers to investigate whether an increased urinary frequency and volume would result. DESIGN: Volume of urinary output and fluid intake were recorded by subjects. Baseline values for urinary frequency and excretion ratio (urination volume:fluid intake) were established 2 days prior to dandelion dosing (8 mL TID) and monitored throughout a 1-day dosing period and 24 hours postdosing. RESULTS: For the entire population (n = 17) there was a significant (p<0.05) increase in the frequency of urination in the 5-hour period after the first dose. There was also a significant (p<0.001) increase in the excretion ratio in the 5-hour period after the second dose of extract. The third dose failed to change any of the measured parameters. CONCLUSIONS: Based on these first human data, T. officinale ethanolic extract shows promise as a diuretic in humans. Further studies are needed to establish the value of this herb for induction of diuresis in human subjects.
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Dandelion : CK(138) : AC(61)
Diseases : Water Retention : CK(35) : AC(10)
Pharmacological Actions : Diuretics : CK(53) : AC(11)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)
______________________________________________________________________
2015
A water extract of Taraxacum mongolicum had a protective effect on lipopolysaccharide induced acute lung injury in mice.

Abstract Title:
Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway.
Abstract Source:
J Ethnopharmacol. 2015 Jun 20 ;168:349-55. Epub 2015 Apr 8. PMID: 25861954
Abstract Author(s):
Chunhua Ma, Lingpeng Zhu, Jing Wang, He He, Xiayun Chang, Jin Gao, Wang Shumin, Tianhua Yan
Article Affiliation:
Chunhua Ma
Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE: Taraxacum mongolicum Hand.-Mazz is a famous medicinal plant in China, has been listed in the Pharmacopoeia of the People's Republic of China and used to treat infection, fever, upper respiratory tract infection, pneumonia, and other infectious diseases. This study aims to evaluate the possible mechanisms responsible for the anti-inflammation effects of water extract of T. mongolicum Hand.-Mazz (WETMHM) on lipopolysaccharide (LPS)-induced inflammatory in acute lung injury.
MATERIALS AND METHODS: Female BALB/c mice were randomly divided into five groups with 10 mice in each group: (1) control group (saline), (2) LPS group, (3) LPS+dexamethasone (LPS+Dex, 2mg/kg, administered by gavage), (4) LPS+WETMHM (5 g/kg, administered by gavage), (5) LPS+WETMHM (10 g/kg, administered by gavage). The cell counting in the bronchoalveolar lavage fluid (BALF) was measured. The animal lung edema degree was evaluated by wet/dry weight (W/D) ratio. The superoxidase dismutase (SOD) activity and myeloperoxidase (MPO) activity were assayed by SOD and MPO kits, respectively. The levels of inflammation mediators including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 were assayed by an enzyme-linked immunosorbent assay method. Pathological changes of lung tissues were observed by hematoxylin and eosin (HE) staining. The levels of P-PI3K, PI3K, P-Akt, Akt, P-mTOR and mTOR were measured by Western blotting.
RESULTS: The data showed that treatment with the WETMHM inhibited LPS-induced inflammation: (1) WETMHM attenuated inflammation cell numbers in the BALF, (2) decreased protein levels of lung PI3K/Akt/mTOR, and (3) improved SOD activity and (4) inhibited MPO activity; (5) histological studies demonstrated that WETMHM substantially inhibited LPS-induced neutrophils in lung tissue.
CONCLUSION: The results indicated that the WETMHM had a protective effect on LPS-induced ALI in mice.
Article Published Date : Jun 19, 2015
Study Type : Animal Study
Additional Links
Substances : Dandelion : CK(138) : AC(61)
Diseases : Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218), Lung Injury: Acute : CK(34) : AC(17), Lung Injury: Neutrophil-Induced : CK(3) : AC(2)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)
______________________________________________________________________
2005

Dandelion (Taraxacum officinale) protects rats from chemical induced pancreatitis.

Abstract Title:
Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rats.
Abstract Source:
World J Gastroenterol. 2005 Jan 28;11(4):597-9. PMID: 15641154
Abstract Author(s):
Sang-Wan Seo, Hyun-Na Koo, Hyo-Jin An, Kang-Beom Kwon, Byung-Cheal Lim, Eun-A Seo, Do-Gon Ryu, Goo Moon, Hong-Yeoul Kim, Hyung-Min Kim, Seung-Heon Hong
Abstract:
AIM: Taraxacum officinale (TO) has been frequently used as a remedy for inflammatory diseases. The aim of this study was to investigate the effect of TO on cholecystokinin (CCK)-octapeptide-induced acute pancreatitis in rats. METHODS: TO at 10 mg/kg was orally administered, followed by 75 microg/kg CCK octapeptide injected subcutaneously three times after 1, 3 and 5 h. This whole procedure was repeated for 5 d. We determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP60 and HSP72, and the secretion of pro-inflammatory cytokines. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally-induced pancreatitis. RESULTS: TO significantly decreased the pancreatic weight/body weight ratio in CCK octapeptide-induced acute pancreatitis. TO also increased the pancreatic levels of HSP60 and HSP72. Additionally, the secretion of IL-6 and TNF-alpha decreased in the animals treated with TO. CONCLUSION: TO may have a protective effect against CCK octapeptide-induced acute pancreatitis.
Article Published Date : Jan 28, 2005
Study Type : Animal Study
Additional Links
Substances : Dandelion : CK(138) : AC(61)
Diseases : Pancreatitis : CK(233) : AC(60)
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
______________________________________________________________________

2008
Dandelion prevents chemical carcinogenesis.
Abstract Title:
Anti-carcinogenic activity of Taraxacum plant. I.
Abstract Source:
J Exp Ther Oncol. 2008;7(4):275-84. PMID: 10408234
Abstract Author(s):
M Takasaki, T Konoshima, H Tokuda, K Masuda, Y Arai, K Shiojima, H Ageta
Article Affiliation:
Kyoto Pharmaceutical University, Japan.
Abstract:
An extract of the roots of Taraxacum japonicum (Compositae) exhibited strong anti-tumor-promoting activities on the two-stage carcinogenesis of mouse skin tumor induced by dimethylbenz[a] anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter, as well as on that induced by DMBA and fumonisin B1. Further, the extract exhibited anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexen amide (NOR-1) as an initiator and TPA as a promoter. These results suggested that an extract of the roots of the Taraxacum plant could be a valuable chemopreventive agent against chemical carcinogenesis.
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Dandelion : CK(138) : AC(61)
Diseases : Skin Cancer : CK(736) : AC(293)
Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)
______________________________________________________________________

2016
Treatment with taraxasterol significantly increased the pain thresholds and reduced the clinical arthritic scores of mice.

Abstract Title:
Protective effect of taraxasterol against rheumatoid arthritis by the modulation of inflammatory responses in mice.
Abstract Source:
Exp Ther Med. 2016 Dec ;12(6):4035-4040. Epub 2016 Nov 2. PMID: 28101182
Abstract Author(s):
Shu-Hua Jiang, Li-Feng Ping, Feng-Yan Sun, Xiao-Lei Wang, Zhi-Juan Sun
Article Affiliation:
Shu-Hua Jiang
Abstract:
Taraxasterol is an effective component of dandelion that has anti-inflammatory effects in vivo and in vitro. The present study was performed to explore whether taraxasterol exhibits a protective effect against rheumatoid arthritis through the modulation of inflammatory responses in mice. Eight-week-old CCR9-deficient mice were injected with a collagen II monoclonal antibody cocktail to create a rheumatoid arthritis model. In the experimental group, arthritic model mice were treated with 10 mg/kg taraxasterol once per day for 5 days. Treatment with taraxasterol significantly increased the pain thresholds and reduced the clinical arthritic scores of the mice in the experimental group compared with those of the model group. Furthermore, treatment with taraxasterol significantly suppressed tumor necrosis factor-α, interleukin (IL)-1β, IL-6 and nuclear factor-κB protein expression levels compared with those in the rheumatoid arthritis model mice. Taraxasterol treatment also significantly reduced nitric oxide, prostaglandin E2 and cyclooxygenase-2 levels compared with those in the rheumatoid arthritis model group. These observations indicate that the protective effect of taraxasterol against rheumatoid arthritis is mediated via the modulation of inflammatory responses in mice.
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Dandelion : CK(138) : AC(61)
Diseases : Rheumatoid Arthritis : CK(745) : AC(125)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), Interleukin-1 beta downregulation : CK(478) : AC(205), Interleukin-6 Downregulation : CK(1137) : AC(354), Nitric Oxide Inhibitor : CK(223) : AC(108), Prostaglandin PGE2 downregulation : CK(96) : AC(46), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
______________________________________________________________________
2011
Dandelion root has a potent action against chemoresistant melanoma without toxicity to healthy cells.

Abstract Title:
The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells.
Abstract Source:
Evid Based Complement Alternat Med. 2011 ;2011:129045. Epub 2010 Dec 30. PMID: 21234313
Abstract Author(s):
S J Chatterjee, P Ovadje, M Mousa, C Hamm, S Pandey
Article Affiliation:
Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, ON, Canada N9B 3P4.
Abstract:
Notoriously chemoresistant melanoma has become the most prevalent form of cancer for the 25-29 North American age demographic. Standard treatment after early detection involves surgical excision (recurrence is possible), and metastatic melanoma is refractory to immuno-, radio-, and most harmful chemotherapies. Various natural compounds have shown efficacy in killing different cancers, albeit not always specifically. In this study, we show that dandelion root extract (DRE) specifically and effectively induces apoptosis in human melanoma cells without inducing toxicity in noncancerous cells. Characteristic apoptotic morphology of nuclear condensation and phosphatidylserine flipping to the outer leaflet of the plasma membrane of A375 human melanoma cells was observed within 48 hours. DRE-induced apoptosis activates caspase-8 in A375 cells early on, demonstrating employment of an extrinsic apoptotic pathway to kill A375 cells. Reactive Oxygen Species (ROS) generated from DRE-treated isolated mitochondria indicates that natural compounds in DRE can also directly target mitochondria. Interestingly, the relatively resistant G361 human melanoma cell line responded to DRE when combined with the metabolism interfering antitype II diabetic drug metformin. Therefore, treatment with this common, yet potent extract of natural compounds has proven novel in specifically inducing apoptosis in chemoresistant melanoma, without toxicity to healthy cells.
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Dandelion : CK(138) : AC(61)
Diseases : Cancers: Drug Resistant : CK(352) : AC(223), Melanoma : CK(285) : AC(149)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Chemosensitizer : CK(394) : AC(286)
Additional Keywords : Chemoresistance : CK(6) : AC(5), Selective Cytotoxicity : CK(158) : AC(112)
​​​​​​​
______________________________________________________________________

You will find much more in the following links on the fucoidan:
______________________________________________________________________
https://www.ncbi.nlm.nih.gov/pubmed/?term=dandelion
http://www.greenmedinfo.com/substance/dandelion

Anti-influenza virus effect of aqueous extracts from dandelion.





Dandelion
_______________________
PubMed
PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books. 
In PubMed
There are  787 on Dandelion.

_______________________

66 Diseases Researched for Dandelion

Oxidative Stress1319
Inflammation1115
Lipopolysaccharide-Induced Toxicity1114
Obesity213
Colitis110
Cytomegalovirus Infections110
Diarrhea110
Dyspepsia110
Water Retention110
Chemically-Induced Liver Damage48
Alcohol Toxicity36
Hepatitis B15
Lipid Peroxidation35
Pancreatic Cancer15
Lung Injury: Acute24
Postmenopausal Disorders: Weight Gain/Obesity13
Acetaminophen (Tylenol) Toxicity12
Arthritis12
Chemotherapy-Induced Toxicity: Mitomycin-C12
Colon Cancer12
Colorectal Cancer12
DNA damage12
Depression12
Depressive Disorder12
Diabetes Mellitus: Type 222
Gastritis12
Hyperlipidemia12
Infertility: Female12
Kidney Damage: Chemically-Induced12
Lead Poisoning12
Liver Fibrosis12
Lung Injury: Neutrophil-Induced12
Pancreatitis12
Prenatal Chemical Exposures12
Prenatal Nutrition: Health of the Offspring12
Rheumatoid Arthritis12
Skin Cancer12
Bacillus Cereus infection11
Bladder Stones11
Brain Inflammation11
Brain: Microglial Activation11
Breast Cancer11
Breast Cancer: Triple Negative11
Cancers: Drug Resistant11
Diabetes Mellitus: Type 2: Prevention11
Fungal Infection11
Gastric Cancer11
Glutathione Deficiency11
Hepatitis C11
Hepatoma11
Hydrogen Peroxide Induced Toxicity11
Influenza11
Kidney Stones11
Leukemia11
Leukemia: Multi-Drug Resistant11
Liver Cancer11
Lung Injury: Smoke-Induced11
Mastitis11
Melanoma11
Neurodegenerative Diseases11
Osteoarthritis11
Prostate Cancer11
Staphylococcus aureus infection11
Staphylococcus aureus: Methicillin-resistant (MRSA)11
Ultraviolet Radiation Induced Damage11
Urolithiasis11



61 Pharmacological Actions Researched for Dandelion

Anti-Inflammatory Agents1623
Tumor Necrosis Factor (TNF) Alpha Inhibitor1219
Antioxidants1418
Antiviral Agents417
Enzyme Inhibitors212
Hepatoprotective612
Apoptotic611
Diuretics211
Enzyme Inhibitors: Pancreatic Lipase110
Interleukin-1 beta downregulation79
Interleukin-6 Downregulation58
Autophagy Up-regulation26
Cyclooxygenase 2 Inhibitors56
Prostaglandin PGE2 downregulation46
Nitric Oxide Inhibitor45
Superoxide Dismutase Up-regulation35
Malondialdehyde Down-regulation24
NF-kappaB Inhibitor44
Nrf2 activation34
Anti-metastatic23
Anticarcinogenic Agents23
Antiproliferative23
Analgesics22
Anti-Fibrotic12
Anti-Ulcer Agents12
Antidepressive Agents12
Antimutagenic Agents12
Contraceptive Agents: Male12
ER alpha receptor up-regulation12
ER beta receptor up-regulation12
Estrogen Receptor Modulators12
Follicle-stimulating hormone receptor (FSHR) up-regulation12
Gastroprotective12
Glutathione Upregulation22
Hypoglycemic Agents22
Hypolipidemic12
Neuroprotective Agents22
Progesterone receptor (PR) up-regulation12
Renoprotective12
Alpha-glucosidase inhibitor11
Anti-Allergic Agents11
Anti-Angiogenic11
Antifungal Agents11
Antimicrobial11
Caspase-3 Activation11
Caspase-8 activation11
Cell cycle arrest11
Chemosensitizer11
Cholagogues and Choleretics11
Cyclooxygenase Inhibitors11
Heme oxygenase-1 inducer11
Heme oxygenase-1 up-regulation11
Interleukin-1 alpha downregulation11
Interleukin-1 alpha upregulation11
Interleukin-8 downregulation11
Intracellular adhesion molecule-1 (ICAM-1)11
Matrix Metalloproteinase-13 (MMP-13) Inhibitor11
Matrix metalloproteinase-1 (MMP-1) inhibitor11
Matrix metalloproteinase-3 (MMP-3) inhibitor11
MicroRNA modulator11
TRAIL sensitizer11
 

Extraction of cage-like sporopollenin exine capsules from dandelion pollen grains. Process of extracting dandelion sporopollenin exine capsules (SECs) from spores. (A) Schematic of dandelion spores and SECs, (i) Defatted Taraxacum officinale pollen, (ii, iii) Spores containing sporoplasmic organelles, and (iv) Dandelion SEC after removal of sporoplasmic organelles and other biomolecules. (B) Flowchart of process to extract empty clean sporopollenin exine capsules (SECs) from defatted dandelion pollen grains

NINFO - MEDFORSK
Stockholm - Charlottenberg - Hamburg - Copenhagen - Oslo - London