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Chaga/Inonotus obliquus

There are 60 good studies on Chaga. Here's a selection:
Abstracts with Chaga Research

Inonotus obliquus polysaccharide has strong activity for ameliorating chronic pancreatitis and a beneficial effect on gut microbiota.

Abstract Title:
Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice.
Abstract Source:
AMB Express. 2017 Dec ;7(1):39. Epub 2017 Feb 14. PMID: 28197985
Abstract Author(s):
Yang Hu, Chunying Teng, Sumei Yu, Xin Wang, Jinsong Liang, Xin Bai, Liying Dong, Tao Song, Min Yu, Juanjuan Qu
Article Affiliation:
Yang Hu
Polysaccharide is efficient in attenuation of metabolic ailments and modulation of gut microbiota as prebiotics. The therapeutic effect of Inonotus obliquus polysaccharide (IOP) on chronic pancreatitis (CP) in mice has been validated in our previous study. However, it is not clear whether IOP is conducive to maintaining the homeostasis between gut microbiota and host. The aim of this study is to testify the potential effects of IOP on gut microbiota composition and diversity in mice with CP. The changes in glutathione peroxidase (GSH-PX), total antioxidant capacity (TAOC), tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), lipase and trypsin levels were measured by commercial assay kits, meanwhile the gut microbiota composition and diversity were analyzed by high throughput sequencing. The IOP treatment increased GSH-PX and TAOC levels, and decreased TNF-α, TGF-β, lipase and trypsin levels in CP mice. It was also observed that gut microbiota in IOP treated groups were less diverse than others in terms of lower Shannon diversity index and Chao 1 estimator. IOP increased the proportion of Bacteroidetes and decreased that of Firmicutes at phylum level. Bacteroideteswas found positively correlated with GSH-PX and TAOC, and Firmicutes correlated with TNF-α, TGF-β, and lipase. In conclusion, administration of IOP could regulate gut microbiota composition and diversity to a healthy profile in mice with CP, and some bacterial phylum significantly correlated withcharacteristic parameters.
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus) : CK(79) : AC(52)
Diseases : Pancreatitis: Chronic : CK(4) : AC(4)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Gastrointestinal Agents : CK(268) : AC(41), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)
Additional Keywords : Microbiota : CK(396) : AC(101), Polysaccharides : CK(5) : AC(3)

Polysaccharides from Inonotus obliquus might be a good candidate for the functional food or pharmaceuticals in the treatment of T2DM
Abstract Title:
Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice.
Abstract Source:
Food Chem Toxicol. 2017 Oct ;108(Pt B):498-509. Epub 2017 Jan 11. PMID: 28087233
Abstract Author(s):
Cong Wang, Zhongqin Chen, Yuxiang Pan, Xudong Gao, Haixia Chen
Article Affiliation:
Cong Wang
Polysaccharides are important bioactive ingredients from Inonotus obliquus. This study aimed to synthesize and characterize a novel I. obliquus polysaccharides-chromium (III) complex (UIOPC) and investigate the anti-diabetic effects in streptozotocin (STZ) induced type 2 diabetes mellitus (T2DM) mice and sub-acute toxicity in normal mice. The molecular weight of UIOPC was about 11.5 × 10 (4) Da with the chromium content was 13.01% and the chromium was linked with polysaccharides through coordination bond. After treatment of UIOPC for four weeks, the body weight, fasting blood glucose (FBG) levels, plasma insulin levels of the diabetic mice were significantly reduced when compared with those of the diabetic mice (p < 0.05). The results on serum profiles and antioxidant enzymes activities revealed that UIOPC had a positive effect on hypoglycemic and antioxidant ability. Histopathology results showed that UIOPC could effectively alleviate the STZ-lesioned tissues in diabetic mice. Furthermore, high dose administration of UIOPC had no obviously influence on serum profiles levels and antioxidant ability of the normal mice and the organ tissues maintained organized and integrity in the sub-acute toxicity study. These results suggested that UIOPC might be a good candidate for the functional food or pharmaceuticals in the treatment of T2DM.
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus) : CK(79) : AC(52)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Polysaccharides : CK(5) : AC(3)

Inonotus obliquus polysaccharides may be a potential broad-spectrum antiviral drug against feline viruses.
Abstract Title:
Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses.
Abstract Source:
Int J Biol Macromol. 2017 Feb ;95:160-167. Epub 2016 Nov 16. PMID: 27865960
Abstract Author(s):
Jin Tian, Xiaoliang Hu, Dafei Liu, Hongxia Wu, Liandong Qu
Article Affiliation:
Jin Tian
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low cytotoxicity. Investigation of the mechanism of action of the compound revealed that IOP treatment induces its inhibitory actions directly on virus particles through blocking viral binding/absorpting. The inhibitory activity against other FCV isolates from China was also identified. More importantly, we found that IOP exhibited broad-spectrum antiviral activity against the feline herpesvirus 1, feline influenza virus H3N2 and H5N6, feline panleukopenia virus and feline infectious peritonitis virus that can contribute to respiratory and gastrointestinal diseases in cats. These findings suggest that IOP may be a potential broad-spectrum antiviral drug against feline viruses.
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus) : CK(79) : AC(52)
Diseases : Cat Diseases : CK(2) : AC(1)
Pharmacological Actions : Antiviral Agents : CK(938) : AC(433)
Additional Keywords : Polysaccharides : CK(5) : AC(3)

Inonotus obliquus polysaccharides might be a potential anti-fatigue pharmacological agent.
Abstract Title:
Effect of Inonotus Obliquus Polysaccharides on physical fatigue in mice.
Abstract Source:
J Tradit Chin Med. 2015 Aug ;35(4):468-72. PMID: 26427119
Abstract Author(s):
Zhong Yue, Zhong Xiuhong, Yang Shuyan, Zheng Zhonghua
Article Affiliation:
Zhong Yue
OBJECTIVE: To evaluate the potential beneficial effects of Inonotus obliquuspolysaccharides (IOP) on the alleviation of physical fatigue in mice.
METHODS: Sixty-four male mice were randomly divided into four groups (n = 16 per group). Mice were orally administered IOP for a period of 14 days at 0, 100, 200 and 300 mg/kg/d, and were assigned to the control, IOP-100, IOP-200, and IOP-300 groups, respectively by the random number table method. Mice in the control group received an oral administration of sterile distilled water. A forced swimming test was performed for 8 mice per group at one hour after the last treatment. The other 8 mice in each group swam for 30 min. Blood, liver and muscle samples were taken after resting for 30 min. Levels of blood urea nitrogen and lactate, as well as glycogen contents of the liver and muscle were measured. Morphology of liver was observed by light microscopy.
RESULTS: IOP extended the swimming time of mice, and increased the glycogen content of liver and muscle, but decreased blood lactic acid and serum urea nitrogen levels, IOP had no toxic effects on major organs such as the liver as assessed by histopathological examinations.
CONCLUSION: IOP might be a potential anti-fatigue pharmacological agent.
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus) : CK(79) : AC(52)
Diseases : Fatigue : CK(312) : AC(49)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)


You will find much more in the following links on the Chaga/Inonotus obliquus:

Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice.

Chaga/Inonotus obliquus
PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books. 
In PubMed
There are  183 on Chaga.


47 Diseases Researched for Chaga/Inonotus obliquus:

Carcinoma: Non-Small-Cell Lung67
Colon Cancer67
Diabetes Mellitus: Type 247
Cancers: All45
Gastric Cancer24
Lipid Peroxidation24
Oxidative Stress34
Breast Cancer23
Cervical Cancer23
Lung Cancer23
Aging Skin12
Anaphylactic Reaction12
Cat Diseases12
Chemotherapy and Radiation Toxicity12
Chronic Kidney Disease (CKD)12
Colon Cancer: Prevention12
Diabetic Nephropathy12
Herpes Simplex Virus Type 122
Inflammatory Bowel Diseases12
Insulin Resistance12
Pancreatitis: Chronic12
Ultraviolet Radiation Induced Damage12
Breast Cancer: Triple Negative11
Cancer Metastasis11
Chemically-Induced Liver Damage11
Chronic Lymphocytic Leukemia11
DNA damage11
HIV Infections11
Hepatitis C11
Hydrogen Peroxide Induced Toxicity11
Kidney Cancer11
Leukemia: Acute promyelocytic leukemia11
Lipopolysaccharide-Induced Toxicity11
Malignant Melanoma11
Melanoma: Metastatic11
Ovarian Cancer11
Prostate Cancer11

46 Pharmacological Actions Researched for Chaga/Inonotus obliquus:

NF-kappaB Inhibitor710
Hypoglycemic Agents59
Anti-Inflammatory Agents58
Malondialdehyde Down-regulation47
Antineoplastic Agents56
Tumor Necrosis Factor (TNF) Alpha Inhibitor36
Antiviral Agents45
Bcl-2 protein down-regulation15
Cell cycle arrest45
Interleukin-1 beta downregulation24
Cyclooxygenase 2 Inhibitors23
Matrix metalloproteinase-9 (MMP-9) inhibitor23
Pancreato Protective Agents23
Superoxide Dismutase Up-regulation23
Anti-Allergic Agents12

Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms.
Interplay between thioredoxin proteins and GSNOR in controlling the biosynthesis of styrylpyrone during the nitrosative burst.. From: Regulation of Anticancer Styrylpyrone Biosynthesis in the Medicinal Mushroom Inonotus obliquus Requires Thioredoxin Mediated Transnitrosylation of S-nitrosoglutathione Reductase.

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