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Piper nigrum - Black Pepper

There are 135 good studies at Black pepper PN. Here's a selection:
Abstracts with Black pepper Research

2015
Short term supplementation with curcuminoid and piperine combination significantly improves oxidative and inflammatory status in patients with MetS.
Abstract Title:
Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis.
Abstract Source:
Clin Nutr. 2015 Jan 7. Epub 2015 Jan 7. PMID: 25618800
Abstract Author(s):
Yunes Panahi, Mahboobeh Sadat Hosseini, Nahid Khalili, Effat Naimi, Muhammed Majeed, Amirhossein Sahebkar
Article Affiliation:
Yunes Panahi
Abstract:
BACKGROUND: Oxidative stress and inflammation have been proposed as emerging components of metabolic syndrome (MetS). Curcuminoids are natural polyphenols with strong antioxidant and anti-inflammatory properties.
OBJECTIVE: To study the effectiveness of supplementation with a bioavailable curcuminoid preparation on measures of oxidative stress and inflammation in patients with MetS. Our secondary aim was to perform a meta-analysis of data from all randomized controlled trials in order to estimate the effect size of curcuminoids on plasma C-reactive protein (CRP) concentrations.
METHODS: In this randomized double-blind placebo-controlled trial, 117 subjects with MetS (according to the NCEP-ATPIII diagnostic criteria) were randomly assigned to curcuminoids (n = 59; drop-outs = 9) or placebo (n = 58; drop-outs = 8) for eight weeks. Curcuminoids were administered at a daily dose of 1 g, and were co-supplemented with piperine (10 mg/day) in order to boost oral bioavailability. Serum activities of superoxide dismutase (SOD) and concentrations of malondialdehyde (MDA) and CRP were measured at baseline and at study end. Regarding the importance of CRP as a risk marker and risk factor of cardiovascular disease, a random-effects meta-analysis of clinical trials was performed to estimate the overall impact of curcuminoid therapy on circulating concentrations of CRP. The robustness of estimated effect size was evaluated using leave-one-out sensitivity analysis.
RESULTS: Supplementation with curcuminoid-piperine combination significantly improved serum SOD activities (p < 0.001) and reduced MDA (p < 0.001) and CRP (p < 0.001) concentrations compared with placebo. Quantitative data synthesis revealed a significant effect of curcuminoids vs. placebo in reducing circulating CRP concentrations (weighed mean difference: -2.20 mg/L; 95% confidence interval [CI]: -3.96, -0.44; p = 0.01). This effect was robust insensitivity analysis.
CONCLUSIONS: Short-term supplementation with curcuminoid-piperine combination significantly improves oxidative and inflammatory status in patients with MetS. Curcuminoids could be regarded as natural, safe and effective CRP-lowering agents.
Article Published Date : Jan 06, 2015
Study Type : Human Study
Additional Links
Substances : Curcuminoids : CK(4681) : AC(2355), Piperine : CK(169) : AC(84)
Diseases : Metabolic Diseases : CK(411) : AC(75), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132)
Additional Keywords : Significant Treatment Outcome : CK(3038) : AC(366)
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You will find much more in the following links on the Black Pepper PN:
http://www.greenmedinfo.com/substance/black-pepper
https://www.ncbi.nlm.nih.gov/pmc/?term=black+pepper
https://www.ncbi.nlm.nih.gov/pmc/?term=piper+nigrum

In vitro anticancer activity of ethanolic extracts of Piper nigrum against colorectal carcinoma cell lines. (a) Ferric reducing antioxidant power units for 50%, 70%, and 100% ethanolic extract of Piper nigrum using ferric reducing antioxidant power method. (b) Percentage inhibition for 50%, 70%, and 100% ethanolic extract of Piper nigrum using 2, 2-diphenyl-1-picrylhydrazyl method. (c) IC50 value (2, 2-diphenyl-1-picrylhydrazyl) of 50%, 70%, and 100% ethanolic extract of Piper nigrum. (d) Percentage inhibition of 50%, 70%, and 100% ethanolic extract of Piper nigrum using human red blood cell membrane stabilization assay Akila Prashant, et al. Int J Appl Basic Med Res. 2017 Jan-Mar;7(1):67-72.

MORE.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327611/
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2016
A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.
Abstract Title:
Cardioprotective effect of curcumin and piperine combination against cyclophosphamide-induced cardiotoxicity.
Abstract Source:
Indian J Pharmacol. 2017 Jan-Feb;49(1):65-70. PMID: 28458425
Abstract Author(s):
Manodeep Chakraborty, Ananya Bhattacharjee, Jagadish Vasudev Kamath
Article Affiliation:
Manodeep Chakraborty
Abstract:
OBJECTIVE: Curcumin is a well-established cardioprotective phytoconstituent, but the poor bioavailability associated with it is always a matter of therapeutic challenge. The present study was undertaken to increase the therapeutic efficacy of curcumin by combining with bio-enhancer like piperine against cyclophosphamide (CP)-induced cardiotoxicity in rats.
MATERIALS AND METHODS: Rats (n = 8) were treated with curcumin (200 mg/kg, p.o.) alone and different dose combination of curcumin (100, 50, 25 mg/kg, p.o.) and piperine (20 mg/kg, p.o.) for 10 days. All the treated groups were subjected to CP (200 mg/kg, i.p.) toxicity on day 1. Twenty-four hours after the last treatment, the effects were evaluated by changes in electrocardiographic (ECG) parameters, serum biomarkers, lipid profile, tissue antioxidants, and histopathological examination. Serum and tissue homogenate parameters were measured by semi-autoanalyzer and spectrophotometer, respectively. Results obtained were assessed by one-way analysis of variance followed by Tukey-Karmer multiple comparison test.
RESULTS: Incorporation of piperine with the doses of 50 and 25 mg/kg with curcumin exhibited significant beneficial effect compared to curcumin alone-treated group. The best effective group was a combination of curcumin 50 mg/kg with piperine 20 mg/kg which showed extremely significant (P<0.001) decrease and increase in ECG and serum biomarker level, respectively, and moderate significant (P<0.01) decrease in lipid profile, antioxidant levels, and histopathological score, compared to curcumin alone-treated group.
CONCLUSION: From this study, it can be concluded that a novel dose combination of curcumin (50 mg/kg) with piperine (20 mg/kg) exhibited profound cardioprotection compared to curcumin (200 mg/kg) alone-treated group.
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4417) : AC(2300), Piperine : CK(169) : AC(84)
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide : CK(78) : AC(28)
Pharmacological Actions : Cardioprotective : CK(1596) : AC(409), Chemoprotective Agents : CK(356) : AC(146)
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2008

Cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.
Abstract Title:
Antigenotoxic Effects of Curcumin and Piperine Alone or in Combination Against 7,12-Dimethylbenz(a)anthracene Induced Genotoxicity in Bone Marrow of Golden Syrian Hamsters.
Abstract Source:
Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926
Abstract Author(s):
Subramanian Balakrishnan, Lakshmanan Vellaichamy, Venugopal P Menon, Shanmugam Manoharan
Article Affiliation:
Department of Biochemistry&Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
Abstract:
ABSTRACT The present study investigates the effect of curcumin and piperine alone or in combination against 7,12-dimethylbenz[a]anthracene (DMBA)-induced genotoxicity in the bone marrow of hamsters. The antigenotoxic effect was evaluated by analyzing the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and chromosomal aberrations. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30 mg/kg b.w). Oral pretreatment of curcumin (80 mg/kg b.w), piperine (50 mg/kg b.w), and curcumin (80 mg/kg b.w) + piperine (50 mg/kg b.w), respectively, for 5 days, significantly reduced the frequency of MnPCEs and the percentage of chromosomal aberrations in the bone marrow of hamsters. The results suggest that cucumin and piperine in combination have a potent antigenotoxic effect as compared to either agent alone in DMBA-induced genotoxicity in golden Syrian hamsters.
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4417) : AC(2300), Piperine : CK(169) : AC(84)
Diseases : DNA damage : CK(1017) : AC(387), Myelotoxicity : CK(31) : AC(8)
Pharmacological Actions : Genoprotective : CK(270) : AC(97)
Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)
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Black Pepper - Piper nigrum 
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PubMed
PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books. 
In PubMed
There are  1014 on Piper nigum and 8489 onBlack Pepper.
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Pharmacological Actions Researched for Black pepper PN.
Antioxidants1739
Anti-Inflammatory Agents1535
Neuroprotective Agents1327
Antiproliferative1625
Apoptotic1325
Cell cycle arrest514
Analgesics212
Anticarcinogenic Agents712
Antidepressive Agents512
Chemopreventive711
Anti-metastatic49
Cardioprotective48
Matrix metalloproteinase-2 (MMP-2) inhibitor38
Matrix metalloproteinase-9 (MMP-9) inhibitor38
NF-kappaB Inhibitor57
Tumor Suppressor Protein p53 Upregulation27
Tumor Necrosis Factor (TNF) Alpha Inhibitor46
Anti-Apoptotic35
Bax/Bcl2 ratio: Increase15
Bcl-2 protein down-regulation15
Caspase-3 Activation15
Caspase-9 Activation15
Hypoglycemic Agents35
Leishmanicidal25
Anticholesteremic Agents24
Anticonvulsants24
Antimicrobial34
Antispasmodic24
Immunostimulatory14
Insecticides14
Interleukin-1 beta downregulation34
Serotonergic14
Angiogenesis Inhibitors23
Anti-Bacterial Agents33
Antineoplastic Agents23
Hypolipidemic23
Immunomodulatory23
Interleukin-6 Downregulation23
Acetylcholinesterase Inhibitor12
Anti-Fibrotic12
Antihypertensive Agents12
Antimutagenic Agents12
Antiparasitic Agents12
Antiprotozoal Agents12
Anxiolytic12
Chemoprotective Agents12
Chemotherapeutic12
Detoxifier12
Enzyme Inhibitors: Pancreatic Lipase12
Gastroprotective12
Genoprotective12
Insecticidal12
Monoamine Oxidase Inhibitors12
Nrf2 activation22
Vascular Endothelial Growth Factor Inhibitors12
Anti-atherogenic11
Cyclooxygenase 1 Inhibitor11
Cyclooxygenase 2 Inhibitors11
Cyclooxygenase Inhibitors11
Endocannabinoid Modulator11
Heme oxygenase-1 inducer11
Interleukin-8 downregulation11
Multidrug Resistance Gene Modulators11
Nitric Oxide Inhibitor11
Prostaglandin PGE2 downregulation11
Radiosensitizer11
Wnt/β-catenin pathway down-regulation11

Pharmacognostic Screening of Piper trichostachyon Fruits and its Comparative Analysis with Piper nigrum Using Chromatographic Techniques. (a) Piper trichostachyon high performance thin layer chromatography profile; (b) Piper trichostachyon high performance thin layer chromatography densitogram; (c) Piper nigrum high performance thin layer chromatography profile; (d) Piper nigrum high performance thin layer chromatography densitogram Vinayak Upadhya, et al. Pharmacogn Mag. 2016 May;12(Suppl 2):S152-S158.
In vitro anticancer activity of ethanolic extracts of Piper nigrum against colorectal carcinoma cell lines. Percentage total phenol in 50%, 70%, 100% ethanolic extract of Piper nigrum using Folin-Ciocalteu method. The inset shows the standard curve of gallic acid Akila Prashant, et al. Int J Appl Basic Med Res. 2017 Jan-Mar;7(1):67-72
In Vitro Evaluation of Essential Oils Derived from Piper nigrum (Piperaceae) and Citrus limonum (Rutaceae) against the Tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). Mortality percentage of R. microplus engorged females exposed to Citrus limonum and Piper nigrum essential oil. Adult Immersion Test (AIT) on mortality of the tick R. microplus. Groups treated with different concentrations of essential oil of C. limonum (a), P. nigrum (b), the combination of both oils (c), and positive control were the commercial acaricides Deltamethrin and Amitraz. In combination oils used the 1 : 1 (vol/vol) concentration of each oil. Results are means ± SD of five experiments. Rafaelle Vinturelle, et al. Biochem Res Int. 2017;2017:5342947.
Preventive Role of Indian Black Pepper in Animal Models of Alzheimer’s Disease. Micrograph of brain section of rats taken piper nigrum 20mg/kg body weight, showing no amyloid plaques Lokraj Subedee, et al. J Clin Diagn Res. 2015 Apr;9(4):FF01-FF04.
Pharmacognostic Screening of Piper trichostachyon Fruits and its Comparative Analysis with Piper nigrum Using Chromatographic Techniques. Vinayak Upadhya, et al. Pharmacogn Mag. 2016 May;12(Suppl 2):S152-S158
The larvicidal effects of black pepper (Piper nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles malaria vector mosquitoes. Clustering of dead Anopheles quadriannulatus larvae 24 h after being fed a powdered black pepper treatment mixture

100 Diseases Researched for Black pepper PN.

Oxidative Stress927
Smoking Cessation: Nicotine Addiction220
Lung Cancer512
Adrenaline: Elevated110
Adrenaline: Low110
Catecholamines: Elevated110
Catecholamines: Low110
Depression410
Hypertension110
Metabolic Diseases110
Muscle Damage: Exercise-Induced110
Neck Pain110
Smoking Cessation110
Stroke: Attenuation/Recovery110
Sympathetic Nervous System Diseases110
Inflammation69
High Fat Diet48
Alzheimer's Disease47
Breast Cancer47
Cancers: All57
Diabetes Mellitus: Type 247
Lipopolysaccharide-Induced Toxicity37
Cognitive Decline/Dysfunction26
Hyperlipidemia36
Obesity36
Brain Inflammation35
Colon Cancer45
Leishmaniasis25
Neurodegenerative Diseases25
Osteosarcoma15
Staphylococcus aureus infection45
Cadmium Poisoning24
Endotoxemia14
Gastrointestinal Diseases24
Liver Cancer24
Malabsorption Syndrome14
Microvilli atrophy14
Vitiligo34
Escherichia coli Infections33
Helicobacter Pylori Infection23
Triglycerides: Elevated23
Alloxan toxicity12
Anxiety Disorders12
Bacterial Infections and Mycoses22
Benzo[a]pyrene-induced Toxicity12
Breast Cancer: Chemically-Induced12
Chemotherapy-Induced Toxicity: Cyclophosphamide12
Copper Toxicity12
DNA damage12
Depressive Disorder12
Diabetes Mellitus: Type 112
Endometritis12
Epilepsy12
Epilepsy: Drug-Induced12
Fat Malabsorption12
Gallstones12
Gastritis12
HPA Axis Dysregulation12
Heavy Metal Toxicity12
High Cholesterol12
Hyperthyroidism12
Indigestion: Fats12
Inflammatory Bowel Diseases12
Insulin Resistance12
Leptin Resistance12
Liver Cancer: Prevention12
Liver Fibrosis12
Low Immune Function: Natural Killer Cells12
Memory Disorders12
Metabolic Syndrome X12
Myelotoxicity12
Myocardial Fibrosis12
Parkinson's Disease12
Pyelonephritis12
Sepsis22
Steatorrhea12
Stress12
Thyroid Diseases12
Toxoplasma gondii Infection12
Toxoplasmosis12
Tumors22
Atherosclerosis11
Autoimmune Diseases11
Bacillus Cereus infection11
Breast Cancer: Triple Negative11
Cancer Stem Cells11
Cancers: Radiation-Resistant11
Colorectal Cancer11
Dental Implantation11
Foodborne Pathogens: Prevention/Food Preservation11
Klebsiella Infections11
Listeria Infections11
Micrococcus luteus infections11
Oral Cancer11
Organ Transplantation11
Osteoclastoma11
Salmonella Infections11
Squamous cell carcinoma11
Staphylococcus aureus: Methicillin-resistant (MRSA)11
Alopecia: Androgenic10

Piper nigrum Leaf and Stem Assisted Green Synthesis of Silver Nanoparticles and Evaluation of Its Antibacterial Activity Against Agricultural Plant Pathogens. Antibacterial activity of silver nanoparticles synthesized by using leaf and stem extract of Piper nigrum. Kanniah Paulkumar, et al. ScientificWorldJournal. 2014;2014:829894.
In vitro anticancer activity of ethanolic extracts of Piper nigrum against colorectal carcinoma cell lines. Cytotoxic analysis of 50% ethanolic extract of Piper nigrum on HCT-116 (a), HCT-15 (b), and HT-29 (c) colon cancer cell lines at 3 time-points Akila Prashant, et al. Int J Appl Basic Med Res. 2017 Jan-Mar;7(1):67-72
The sRNAome mining revealed existence of unique signature small RNAs derived from 5.8SrRNA from Piper nigrum and other plant lineages. Distribution and abundance pattern of ribosomal RNA derived small RNAs in Piper nigrum small RNA libraries (A) Distribution of unique srRNA candidates against black pepper rRNA. (B) Abundant srRNA from Pn_CL (upto100 rpm) mapped against rRNA. Most of the abundant reads were mapped at the 5.8S rRNA region. (C) The proportion of 5.8S rRFs in the Pn_CL, Pn_IL and Pn_IR libraries. (D) The length categorisation of 5.8S rRFs among the three libraries. Srinivasan Asha, et al. Sci Rep. 2017;7:41052
The larvicidal effects of black pepper (Piper nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles malaria vector mosquitoes. Mean mortalities of laboratory-reared Anopheles larvae 24 h after being fed powdered black pepper (Piper nigrum) at various concentrations. The dose value represents the percentage of black pepper in a 50 mg treatment mixture. 0 % represents the control group which was fed standard larval food only and 100 % represents a treatment comprised of black pepper only. A One-way ANOVA and Tukey HSD post-hoc comparisons were used for each strain to determine significant differences in mortality at each dose compared to that of the relevant control at 95 % confidence. a Anopheles arabiensis strains. b Anopheles gambiae (GAH) and An. coluzzii (SILC & SUA) strains. c Anopheles quadriannulatus. d Anopheles funestus strains Michael Samuel, et al. Parasit Vectors. 2016;9:238

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